With the traditional administration mode is different, transdermal drug delivery formulations with controlled release drug, prolong the effective time, avoid hepatic first pass effect and side effect of gastrointestinal tract, prevent injection pain, patients can self medication and reduce human blood concentration changes of peak and valley of advantage.
Many anticancer drugs can produce undesirable side effects in the use of large doses, such as the liver toxicity. The transdermal drug delivery can avoid the first pass effect, therefore, the transdermal drug delivery method for reducing dosage can reduce the toxicity of anticancer drugs on the human body. At the same time by changing the administration area adjusting dosage, reduce the difference between individual and individual difference, the patient can self medication, can also be discontinued at any time.
The key for the transdermal delivery of development is to overcome the barrier of skin, make the drug transdermal permeation reach the treatment amount in a certain period of time. As a fundamental goal, physical chemistry of different permeation methods continue to emerge, including sonophoresis, chemical penetration enhancers, iontophoresis and electroporation.
At present western medicine transdermal preparation more than 10 varieties listed, one of the most representative of the transdermal preparation including the people to stop smoking nicotine patch, painkillers (such as fentanyl patch), sedative, clonidine treatment of motion sickness Scopolamine Patches, medicine for treating cardiovascular disease (nitroglycerin) patch, the use of estradiol in postmenopausal women patch and treatment of male diseases with testosterone patch. In recent years, with the development of biological engineering technology, people in addition to the large number of these small molecule hormones and analgesic drug transdermal preparation, but also for some large biological molecule polypeptide or protein drugs were studied, trying to make it into the safe and convenient transdermal patch, so as to solve the clinical application of these defects in biological macromolecules the drug itself exists.
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